Medizym T.R.A. Human: A Quantitative Immunoassay for Graves' Disease Diagnosis and Control

The Medizym® T.R.A. human is a valuable tool in the differential diagnosis of hyperthyroidism and the control of Graves’ disease, an autoimmune disorder characterized by the presence of Thyrotropin receptor autoantibodies (TRAb) that mimic the effects of Thyrotropin (TSH) on thyroid cells, leading to increased levels of thyroxine (T4) and triiodothyronine (T3) in the blood.

Quantitative Immunoassay Detection of Antibodies against Thyrotropin Receptor in Human Serum

This quantitative immunoassay is designed to detect antibodies against TSH receptors in human serum using the competitive ELISA method. The microtiter plate is coated with test-specific antigens, and if antibodies are present in the sample, they bind to the antigens. A second biotinylated tracer antibody targets the remaining accessible binding sites of the coated antigen. Streptavidin conjugated with the enzyme peroxidase binds the immobilized biotinylated antibody, and a colorless substrate is converted into the colored product by the peroxidase. The signal intensity of the reaction product is indirectly proportional to the antibody activity in the sample.

Graves' Disease Diagnosis and Control

The Medizym® T.R.A. human aids in the diagnosis of Graves’ disease by detecting TRAb in the patient's serum. This test is intended to aid in the differential diagnosis of hyperthyroidism and the control of Graves’ disease. It is a reliable and accurate method for determining the presence of specific antibodies in the patient's sample.

Immunoassay for Graves' Disease

The Medizym® T.R.A. human is manufactured by Medipan GmbH, Germany, and is a valuable tool in the diagnosis and control of Graves’ disease. This quantitative immunoassay detects TRAb in human serum using the competitive ELISA method. It is a reliable and accurate method for determining the presence of specific antibodies in the patient's sample.

Key Features:

Quantitative immunoassay for the detection of antibodies against Thyrotropin (TSH) receptor in human serum
Aids in the differential diagnosis of hyperthyroidism and the control of Graves’ disease
Uses the competitive ELISA method to determine the presence of specific antibodies in the patient's sample
Microtiter plate is coated with test-specific antigens
Biotinylated tracer antibody targets the remaining accessible binding sites of the coated antigen
Streptavidin conjugated with the enzyme peroxidase binds the immobilized biotinylated antibody
Colorless substrate is converted into the colored product by the peroxidase
Signal intensity of the reaction product is indirectly proportional to the antibody activity in the sample

The Medizym® T.R.A. human is an effective diagnostic tool that aids in the management of Graves’ disease. Its accuracy and reliability make it an essential component in the diagnosis and control of this immunological disorder.